Pharmacokinetics of roxitharomycin in paediatrics
- 1 January 1987
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 20 (suppl B) , 101-106
- https://doi.org/10.1093/jac/20.suppl_b.101
Abstract
Macrolides are well known for their high lipid solubility and good tissue penetration. The pharmacokinetic properties of roxithromyrin, a new semisynthetic macrolide, appear to be very interesting in healthy adult patients. Five paediatric pharmacokinetic studies are summarized and show that the pharmacokinetic properties of roxithromycin in paediatrics are very similar to those previously reported in adults and suggest that the same dose every 12 h is appropriate in paediatrics, 2.5 mg/kg. The diffusion of roxithromycin into upper respiratory tract tissues appears to be good in children.Keywords
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