SEVERE REACTIONS TO PENICILLIN

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Abstract
The oral and topical use of penicillin, in such forms as tablets, lozenges, troches, wet dressings, ointments, sprays and nose and eye drops in the treatment of comparatively minor ailments may sensitize many persons to this valuable antibiotic. Two severe sensitization reactions to penicillin are reported. REPORT OF CASES Case 1.— S. B., a white man aged 57, consulted us on July 16, 1946, for chronic furunculosis of ten months' duration. He denied a history of active fungous disease and a personal or family history of allergy. In October 1945, he noted numerous furuncles on his upper extremities. Penicillin ointment was prescribed in November, and, after three weeks of use, an erythematous edematous eruption appeared on the face and neck. The eruption soon became generalized, necessitating hospital care for three months. On July 16, 1946, 300,000 units of penicillin in peanut oil and wax (Romansky formula) was administered intramuscularly for

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