The practice guidelines development cycle: a conceptual tool for practice guidelines development and implementation.

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Abstract
PURPOSETo develop a conceptual tool for the systematic development of cancer treatment practice guidelines.MATERIALS AND METHODSThe guidelines development tool, the Practice Guidelines Development Cycle, was derived from observing an evidence-based practice guidelines initiative at a comprehensive cancer center in Ontario, Canada, and from a literature review that uncovered barriers to guidelines development and implementation. Based on the literature findings and direct observations of how clinicians struggled with evidence-based guidelines development, we evolved a framework to incorporate clinical and administrative factors (eg, costs) into evidence-based guidelines. Use of the Practice Guidelines Development Cycle is illustrated with a clinical example (the use of adjuvant systemic therapy in good-risk, node-negative premenopausal breast cancer patients).RESULTSThe result is the Practice Guidelines Development Cycle, which consists of eight sequential steps, from topic selection to policy formulation....

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