Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific
Open Access
- 1 August 2009
- journal article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 11 (4) , 414-422
- https://doi.org/10.1215/15228517-2008-096
Abstract
Both genetic and epigenetic mechanisms contribute to meningioma development by altering gene expression and protein function. To determine the relatiKeywords
This publication has 37 references indexed in Scilit:
- WNK2 modulates MEK1 activity through the Rho GTPase pathwayCellular Signalling, 2008
- Epigenome scans and cancer genome sequencing converge on WNK2 , a kinase-independent suppressor of cell growthProceedings of the National Academy of Sciences, 2007
- Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningiomaJournal of Neurosurgery, 2007
- Patterns of somatic mutation in human cancer genomesNature, 2007
- Restriction Landmark Genomic Scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinationsBMC Genomics, 2007
- The Consensus Coding Sequences of Human Breast and Colorectal CancersScience, 2006
- WNK1 Activates SGK1 by a Phosphatidylinositol 3-Kinase-dependent and Non-catalytic MechanismJournal of Biological Chemistry, 2005
- MeningiomasThe Lancet, 2004
- Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumorsNature Genetics, 2002
- Human Hypertension Caused by Mutations in WNK KinasesScience, 2001