A CASE OF MULTIPLE ENDOCRINE ADENOMATOSIS (TYPE 1) WITH NESIDIOBLASTOSIS, TERMINATING WITH AN EXOCRINE PANCREATIC CARCINOMA

Abstract
A patient is described with multiple endocrine adenomatosis Type I, characterized by pituitary-dependent Cushing''s Syndrome, marked hyperprolactinemia, primary hyperparathyroidism and hyperinsulinism leading to hypoglycemia. The patient subsequently developed an exocrine pancreatic carcinoma at the age of 32 yr from which she died. An additional finding was the demonstration by immunocytochemistry of nesidioblastosis in the pancreas.