Pulmonary candidiasis. A clinical and pathological correlation

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Abstract
Patients [30] with systemic Candida infection underwent autopsy during a 13-yr prospective study. Patients [11] had tissue-verified pulmonary candidiasis. Nine of these patients had hematogenous dissemination, as evidenced by multiple organ invasion; 2 had aspiration pneumonia with lung involvement only. Aspiration Candida pneumonia is rare. Pulmonary candidiasis usually arises from a focus of infection implanted during hematogenous dissemination. An infected in-dwelling venous catheter was the source of candidemia in 6 of these patients. Organisms in the lumen of pulmonary vessels caused a necrotizing vasculitis and appeared to invade the parenchyma from these areas.

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