Inactivation of endogenous vasodilator material: a detoxification process of the lung.

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Abstract
The hindlimb of an anesthetized dog was perfused at a constant flow either with arterial or venous blood by a peristaltic pump alone or in combination with a sponge oxygenator. During venous perfusions, the paw blood flow rose to 171% of that obtained from arterial perfusions; paw resistance during venous perfusion fell to 39% of arterial purfusion values. There was no significant difference in vascular resistance of the paw between the perfusion of arterial blood and arterial blood after passage through the oxygenator. There was no significant difference between the perfusion of venous blood and venous blood after passage through the oxygenator. It was concluded that: (1) venous blood has vasodilating activity, (2) this property is not affected by saturation of the blood with O2, and (3) a normal pulmonary function is to trap or inactivate this material.