Immunostaining of antral gastrin cells is quantitatively increased in Helicobacter pylori gastritis

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Abstract
The amount of gastrin-like immunostaining in gastrin (G) cells of the antral mucosa was quantified using a computer-assisted method of measuring immunoreaction product. Biopsies from 25 patients without Helicobacter-like organisms and 60 patients with varying degrees of infection were immunostained for gastrin. Twenty-five G cells from each patient were measureed both sunjectively and by image analusis. Gastrin-like immunoreactivity was found to be significantly increased in the presence of Helicobacter-like organisms.