Lipid Composition of the Carcass of Mice Bearing the Krebs-2 Carcinoma.

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Abstract
The lipid composition of the carcass of mice bearing the Krebs-2 carcinoma for periods varying from 1 to 5 weeks was determined. The only change of questionable significance occurred after 5 weeks of tumor growth at which time the carcass neutral lipids were decreased and the phosphatides were increased. Prior to the 5th week the neutral lipids increased somewhat. No change was found in the amount of the carcass neutral lipid classes; the triglycerides, sterol esters, cholesterol, mono- and diglycerides and free fatty acids as a result of the growth of the Krebs-2 carcinoma. Furthermore no significant change was found in the fatty acid composition of the free fatty acids, sterol esters and triglycerides of the carcass lipids following growth of the carcinoma from 1 to 5 weeks. Either not all tumors bring about a decrease in the lipids of the host, or that the lipid loss may not occur in all species as a result of tumor growth or that metastases, such as are found as a result of the growth of the Walker carcinosarcoma, are necessary to deplete the lipids of the host.