A Study of Rachitogenic Diets Composed of Purified Food Materials

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Abstract
A number of low-phosphorus diets rachitogenic for the rat and composed of purified food material have been described. Blood fibrin was used as the protein in most of the diets. A fair degree of rickets can be obtained with casein if fed at a level of not over 12%. Apparently the antirachitic activity of casein is due entirely to the large amount of phosphorus contained in this protein. In order to produce severe rickets in the rat on diets containing 3% CaCO3 the available phosphorus must not be greater than approximately 0.1%.