Experimental Evaluation of Five Liver-Spleen Specific CT Contrast Agents

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Abstract
Five experimental liver-spleen specific computed tomography (CT) contrast agents [ethyl diiodostearate and ethyl monoiodostearate, 4 different emulsions], all of which are aqueous emulsions of iodinated vegetable oils, were tested. These compounds were compared with ethiodized oil emulsion 13 (EOE-13) and with a 5% dextrose in water control. Three animal/dose level models with both histology and CT were evaluated to determine the best screening method for compounds of this type. A rat/high dose model, a rat/medium dose model and a rabbit/low dose model were compared; the best discrimination was seen with the rabbit/low dose model. Histology of liver, spleen and lung did not correlate with the attenuation values obtained from CT. Apparently use of CT and a rabbit/low dose model is superior for screening compounds of this type. Of the compounds tested, only 1, an emulsion of ethyl monoiodostearate (compound 208E), approached the effectiveness of EOE-13.

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