COMPUTER SIMULATION OF TUMOR RECURRENCE

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Abstract
Computer simulations have been conducted to provide a realistic model of tumor recurrence in a cancer patient, following treatment. The simulation model incorporates description of the temporal organization of various biological processes underlying tumor development at the cellular level: proliferation, differentiation, death of tumor cells, growth control in neoplastic tissues along with the tumor treatment effect. The prime object of our concern is whether the simple parametric model of tumor recurrence proposed by Hoang et al. [6] allows estimation of actual value of the tumor growth potential. A good fit has been demonstrated of the parametric model when applied to the samples of simulated tumor recurrence times as well as to real data samples of tumor recurrence in breast cancer patients with various regimen of radiotherapy.

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