Urine Osmolality and δ-Aminolevulinic Acid Excretion

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Abstract
A mathematical model for the relationship between urine osmolality and δ-aminolevulinic acid (DALA) in the urine has been developed from a study of three populations exposed to environmental levels of lead and two populations exposed to industrial levels of lead. The equation derived from the model indicates that urine DALA is principally a function of urine osmolality when the level of lead exposure, as reflected in the urine lead, is below a threshold level. Urine DALA becomes principally a function of lead exposure when another critical level is reached. By considering the influence of urine osmolality, urine DALA becomes a more sensitive means of measuring the effect of environmental levels of lead on populations.

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