A Species Difference with Regard to the Effect of Cortisone Acetate on Body Weight, γ-Globulin and Circulating Antitoxin Levels

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Abstract
It is generally agreed that the administration of the 11–oxysteroid hormones of the adrenal cortex to the commonly used experimental animals, the rat and the rabbit, produces involution of lymphoid tissue. Since lymphoid tissue is an important site of formation of antibody, several workers have attempted to correlate the effects of adrenal steroids on lymphoid tissue with their effects on immunity. The effect of the 11–oxysteroid adrenal hormones on the immunity of experimental animals, as judged by the amount of circulating antitoxin present in the blood, is not, however, a matter of general agreement. Different workers have obtained widely diverse and conflicting results.
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