Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
- 18 February 2003
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 6 (3) , 223-230
- https://doi.org/10.1038/nn1017
Abstract
Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.Keywords
This publication has 40 references indexed in Scilit:
- Regulation of Cortical Dendrite Development by Slit-Robo InteractionsNeuron, 2002
- Short-Range and Long-Range Guidance by Slit and Its Robo Receptors: A Combinatorial Code of Robo Receptors Controls Lateral PositionCell, 2000
- Selecting a Longitudinal PathwayCell, 2000
- Conservation and divergence of axon guidance mechanismsCurrent Opinion in Neurobiology, 1999
- Chimeric Axon Guidance Receptors: The Cytoplasmic Domains of Slit and Netrin Receptors Specify Attraction versus RepulsionCell, 1999
- The Molecular Biology of Axon GuidanceScience, 1996
- commissureless Controls Growth Cone Guidance across the CNS Midline in Drosophila and Encodes a Novel Membrane ProteinNeuron, 1996
- Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midlineNeuron, 1993
- slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.Genes & Development, 1990