Identification of a shark sequence resembling the major histocompatibility complex class I alpha 3 domain.
Open Access
- 15 March 1992
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 89 (6) , 2209-2212
- https://doi.org/10.1073/pnas.89.6.2209
Abstract
Elasmobranchs (sharks and rays) branched off from the vertebrate line leading to the mammals more than 400 million years ago. They do not exhibit acute allograft rejection, and so far no report has pointed to the presence of major histocompatibility complex (MHC) antigen-like molecules in elasmobranchs. Here we demonstrate the existence of a gene in the shark (Triakis scyllia) genome with a sequence that resembles the MHC class I alpha 3 domains of other vertebrates. Several amino acids considered to be important for the interaction of the T-cell coreceptor CD8 with the MHC class I alpha 3 domain are conserved in the shark sequence.Keywords
This publication has 25 references indexed in Scilit:
- STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULESAnnual Review of Biochemistry, 1990
- A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2Nature, 1990
- Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytesNature, 1989
- T-cell antigen receptor genes and T-cell recognitionNature, 1988
- The Immunoglobulin Superfamily—Domains for Cell Surface RecognitionAnnual Review of Immunology, 1988
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Structure of the human class I histocompatibility antigen, HLA-A2Nature, 1987
- Major reorganization of immunoglobulin VH segmental elements during vertebrate evolutionNature, 1986
- Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ dScience, 1983
- Regions of allelic hypervariability in the murine Aα immune response geneCell, 1983