Significant loss of bone mass in patients with early, active ankylosing spondylitis: A followup study

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Abstract
Objective To analyze whether inflammatory disease activity plays a substantial role in the loss of bone mass observed in ankylosing spondylitis (AS) patients who have not yet developed ankylosis. Methods A longitudinal cohort study of 34 patients with early AS (duration 2 at study entry versus 0.961 gm/cm2 at followup [P = 0.005]) and femoral neck (0.849 gm/cm2 versus 0.821 gm/cm2 [P = 0.015]), which represented losses of 5% and 3%, respectively. In contrast, no significant reduction in bone mass was observed in patients with inactive AS. As expected, serum IL-6 levels were significantly higher in patients with active AS than in those with inactive disease (mean ± SD 8.3 ± 9 pg/ml versus 2.8 ± 5 pg/ml [P = 0.008]). No significant differences were observed between the 2 groups in any of the other variables analyzed. Conclusion The observation that loss of bone mass in AS occurred only in patients with persistent active disease strongly suggests that inflammatory activity of the disease itself plays a major role in the pathophysiology of the early bone mineral disorders observed in these patients.