Tumor Hybrid Cells: An Immunotherapeutic Agent2
- 1 May 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (5) , 1541-1545
- https://doi.org/10.1093/jnci/52.5.1541
Abstract
Hybrid tumor cells were formed by the spontaneous and virus-induced fusion of EL-4 lymphoma cells with C3H fibroblasts. Some resultant hybrid cell lines specifically immunized C57BL/6 and (C57BL/6 × C3H)F1 mice against subsequent lethal EL-4 challenge. The immune response to the hybrid tumor cells was superior to the response to irradiated EL-4 cells. The possibility of hybrid tumor cells as a specific immunotherapeutic agent was discussed.Keywords
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