Fungicide‐induced contact dermatitis

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Abstract
Tetrachloroisophthalonitrile (TCPN) is an agricultural and horticultural fungicide used in many parts of the world. In Northern Europe it is also used as a wood preservative. The substance has well-known toxic properties through skin contact, and has recently been reported as inducing allergic contact dermatitis. An epidemic of contact dermatitis in a Norwegian wooden-ware factory was reported, which was attributed to TCPN. Of 20 workers, 14 had skin complaints which were work related. Half of these cases were of allergic origin. The toxic and allergic properties of TCPN render this compound unsuitable for use in the woodenware industry. A re-evaluation of its use in agriculture and horticulture seems appropriate.

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