In-vitro activity of temafloxacin for Gram-positive pathogens
- 1 January 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 28 (suppl C) , 9-14
- https://doi.org/10.1093/jac/28.suppl_c.9
Abstract
The antimicrobial activity of tcmafioxacin against aerobic Gram-positive cocci was compared to that of ciprofloxacin, ofloxacin, fleroxacin and pefloxacin using the broth microdilution technique. Temafloxacin was mom active than the other four fluoroquinolones, particularly for viridans streptococci and Streptococcus pneumoniaeniae . The MIC 90 of temafloxacin was at least four-fold lower than that of ciprofloxacin and ofloxacin for viridans strtptococci and penicillin-susceptible pneumococci. The MIC 50 s and MIC 90 s of temafloxacin were equal to or lower than those of the other fluoroquinolones for rnethicillin-susceptible Staphylococnu aureus (MSSA), methicillin-resistant S.aureus (MRSA), and methicillin-susceptible and methicillin-resistant coagulasc-negative staphylococci Temafloxadn was more active against all the other Gram-positive aerobes (except Enterococcus faecalis ) tested than the other fluorquinolones.Keywords
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