Activity of enzymes involved in pyrimidine nucleotide synthesis during uterine growth in cyclic rats

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Abstract
The pyrimidine nucleotide salvage enzymes, uridine and thymidine kinases, and the enzyme, aspartate carbamyltranferase, involved in de novo synthesis were investigated to assess their relative contributions to the RNA and DNA precursor requirements of uterine growth in cyclic rats. Only asparatate carbamyltransferase reflected the known fluctuations in plasma estradiol-17.beta. and uterine mitotic activity, being minimal at diestrus 1 and maximal at proestrus. Treatment of ovariectomized rats with estradiol-17.beta. stimulated carbamyltransferase activity but cycloheximide prevented this response, indicating the association between the enzyme and this hormone. Uridine kinase activity did not vary during the estrous cycle, but there were peaks of thymidine kinase activity on the days of proestrus and the 1st day of diestrus.

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