Depsidone synthesis. Part 21. A new synthesis of grisa-2′,5′-diene-3,4′-diones
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 403-411
- https://doi.org/10.1039/p19820000403
Abstract
Treatment of suitably substituted methyl 2-phenoxybenzoates with titanium(IV) chloride and dry hydrogen chloride afforded grisa-2′,5′-diene-3,4′-diones in high yield. The structures of these compounds followed from their thermal stability, their methanolysis to methyl 2-(4-hydroxyphenoxy)benzoates, and their reductive cleavage to 2,4′-dihydroxybenzophenones. Treatment of the benzophenones with base gave xanthones. An attempt to synthesize dehydrogriseofulvin (1) by this method failed.This publication has 8 references indexed in Scilit:
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