Molecular Basis of the Attenuation Exhibited by Molecularly Cloned Highly Passaged Chicken Anemia Virus Isolates
Open Access
- 15 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (16) , 8472-8474
- https://doi.org/10.1128/jvi.76.16.8472-8474.2002
Abstract
Chimeric virus experiments indicated that the pathogenicity and monoclonal antibody reactivity differences between two molecularly cloned, highly passaged chicken anemia virus isolates could be attributed to the VP1 amino acid change at residue 89. The introduction of this change into a pathogenic cloned low-passage isolate was not sufficient to cause attenuation.Keywords
This publication has 13 references indexed in Scilit:
- Characterisation of a chicken anaemia virus variant population that resists neutralisation with a group-specific monoclonal antibodyArchiv für die gesamte Virusforschung, 2001
- Identification of a genetic determinant of pathogenicity in chicken anaemia virusJournal of General Virology, 2001
- Antigenicity and pathogenicity characteristics of molecularly cloned chicken anaemia virus isolates obtained after multiple cell culture passagesArchiv für die gesamte Virusforschung, 1999
- Virus Taxonomy at the XIth International Congress of Virology, Sydney, Australia, 1999Archiv für die gesamte Virusforschung, 1999
- PCR-ligation-PCR mutagenesis: a protocol for creating gene fusions and mutations.1995
- Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragmentsArchiv für die gesamte Virusforschung, 1992
- Chicken anaemia agent: A reviewAvian Pathology, 1991
- Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycleJournal of Virology, 1991
- Purification and biochemical characterization of chicken anaemia agentJournal of General Virology, 1990
- Chicken Anemia Agent in the United States: Isolation of the Virus and Detection of Antibody in Broiler Breeder FlocksAvian Diseases, 1989