Preparation of deuterium labelled α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA)
- 1 October 1981
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 18 (10) , 1479-1484
- https://doi.org/10.1002/jlcr.2580181012
Abstract
The preparation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) with deuterium α to the carboxylic acid group (2) and in the exocyclic methyl group (5), respectively, are described. The deuterium labelled AMPA (2) was synthesized by hydrolysis and decarboxylation of the corresponding di‐ester (1), whereas the deuterium labelled AMPA (5) was prepared via a catalytic deuteration of the bromoderivative (3).Keywords
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