Effects of gastrointestinal hormones on vascular smooth muscle

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Abstract
The effects of the gastrointestinal hormones secretin and cholecystokinin (CCK) were investigated on rat portal-vein mechanical activity. Doses of 0.03–0.60 units/ml Boots secretin; 0.18–0.60 units/ml, pure, natural secretin; and 0.12–0.60 units/ml CCK elicited dose-dependent decreases in amplitude and simultaneous increases in frequency of spontaneous contractions that were unaffected by α- or β-adrenergic or cholinergic blockade. These effects were mimicked by isoproterenol, theophylline, and cyclic AMP, and all agents tested were also effective in reducing K- or norepinephrine-induced tension. Additionally, subthreshold doses of CCK and secretin elicited responses when given in combination, and the effects of the hormones at all doses were potentiated by theophylline, indicating an interaction between these hormones on rat portal vein that may involve cyclic AMP. It is suggested that part of the mechanism of hormone-induced mesenteric vasodilation smooth muscle.

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