Gastrin and Gastrointestinal Dyspepsia in Pregnancy

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Abstract
Fasting serum gastrin (SG) concentration and the SG response to a standard protein meal were investigated in 8 women with upper gastrointestinal dyspepsia in the 36th week of pregnancy and again 8 wk after parturition, when the dyspepsia had disappeared. The fasting SG concentration was significantly higher (P < 0.05) during pregnancy than postpartum, whereas no statistically significant difference was found between the SG response to a protein meal stimulation during pregnancy vs. postpartum. The demonstrated variations in gastrin secretion during and after pregnancy offer no explanation for the upper gastrointestinal intestinal dyspepsia of these patients.