Effect of hypophysectomy and growth hormone administration on somatostatin and gastrin content in the stomach of rats.
- 1 January 1981
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 28 (3) , 257-260
- https://doi.org/10.1507/endocrj1954.28.257
Abstract
The effect of hypophysectomy and bovine growth hormone (GH) administration on somatostatin (SRIF) content as well as gastrin content in the rat stomach was investigated. SRIF content was determined by a specific radioimmunoassay. The total SRIF content in the stomach had decreased 4 weeks after hypophysectomy but was restored significantly in those rats which were subjected to bovine GH administration for 7 days after hypophysectomy. Furthermore, in control rats, an increase in SRIF content in the stomach was observed after 7 days of GH administration. Similar changes in total content of gastrin were observed after hypophysectomy and bovine GH administration, although these changes were not significant. These results indicate that GH may influence gastric function through changes in SRIF and gastrin content in the stomach.This publication has 1 reference indexed in Scilit:
- Pancreatic and Gastric D Cell Function in Hypophysectomized Dogs*Endocrinology, 1979