Cloning of cDNAs Encoding Multiple Subtypes of Feline Interferon-.ALPHA. from the Feline Epitherial Cell Line
- 1 January 2004
- journal article
- Published by Japanese Society of Veterinary Science in The Journal of Veterinary Medical Science
- Vol. 66 (6) , 725-728
- https://doi.org/10.1292/jvms.66.725
Abstract
Mammalian interferon (IFN)-alpha consists of a 23-amino acid signal peptide and a 166-amino acid mature protein. Feline (Fe) IFN-alpha has an extra unique molecule consisting of a 171-amino acid mature protein with a 5-amino acid insertion. We cloned eight new subtypes of cDNA encoding FeIFN- alpha from a feline epithelial cell line. Among all the FeIFN-alpha subtypes, including six that have previously been reported, the variations were found to be far less than those of IFN-alphas of other animals.Keywords
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