Treatment of Brucella canis and Brucella abortus in Vitro and in Vivo by Stable Plurilamellar Vesicle-Encapsulated Aminoglycosides

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Abstract
Stable plurilamellar vesicles (SPLVs) entrapping aminoglycosides were used to treat infections due to Brucella species (Brucella canisand Brucella abortus). SPLV-entrapped antibiotics effectively eliminated internalized B. canisin cultures of resident murine peritoneal macrophages and internalized B. abortusin cultures of resident guinea pig peritoneal macrophages. In vivo studies demonstrated that SPLV-entrapped aminoglycosides administered to B. canis-infected mice and B. abortus-infected guinea pigs effectively eliminated bacteria from infected organs. The dosage schedule used involved two intraperitoneal administrations of SPLV-entrapped aminoglycosides at three-day intervals. The results demonstrate the superiority of SPLV-entrapped aminoglycosides to free aminoglycosides in effecting elimination of facultative intracellular bacteria in vitro and in vivo. The use of SPLVs as a drug carrier has broad application to treatment of infections due to other organisms.

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