INDIRECT EFFECT OF CYCLOPHOSPHAMIDE ON THE LUNG-TUMOR COLONY FORMATION AND ON THE CONDITIONED MEDIA ACTIVITY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 31  (1) , 37-42
Abstract
Mice pretreated with cyclophosphamide (CY) had more tumor colonies in lungs following i.v. injection than their intact counterparts. CY treated mice restored with spleen cells showed incomplete reduction of the artificial metastasis in lungs. Conditioned media prepared from lungs contain 2 factors: stimulating and inhibiting cell proliferation in vitro. Conditioned media from CY treated mice have a decreased inhibitory ability.