Sparteine oxidation by the human liver: Absence of inhibition by mephenytoin

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Abstract
Recent population data suggest independence of the genetic polymorphisms in mephenytoin and sparteine/debrisoquine oxidation. Human liver preparations were used to test whether mephenytoin competes with sparteine for binding to the genetically variable cytochrome P-450, which mediates metabolism of both sparteine and debrisoquine. Mephenytoin failed to inhibit in vitro sparteine oxidation. The polymorphism of sparteine/debrisoquine metabolism is evidently not related to that of mephenytoin.

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