Effect of chronic administration of aldosterone on bile secretion, on liver cytochrome P-450, and on red blood cell sodium content.

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Abstract
Male adult albino rabbits received, during a period of 2 wk, a daily s.c. injection of aldosterone, 150 .mu.g/kg body wt. Twenty-four h after the last injection, bile was collected during 2 h under anesthesia; the liver was then removed and submitted to cytochrome P-450 measurements and microscopic analysis. Red blood cell Na content was measured before and after aldosterone treatment. In animals treated with aldosterone, compared with controls, the following results were found: a significant diminution (P < 0.01) of bile flow rate, of Na biliary excretion and of biliary bile acid output; a significant increase (P < 0.001) of liver cytochrome P-450; hyaline modifications of hepatocytes without necrosis or steatosis; a proliferation of liver smooth endoplasmic reticulum; an increase (P < 0.001) of red blood cells Na content.

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