INFLAMMATORY PSEUDOHISTOPLASMOSIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 17  (8) , 461-465
Abstract
In patients with multifocal choroiditis, presumed ocular histoplasmosis syndrome (POHS) is often diagnosed. POHS typically is unassociated with inflammatory activity in the ocular media. A group of patients had a pattern of multifocal choroidal spots reminscent of POHS with active signs of inflammation in the anterior and vitreous chambers. Of the 28 patients, 43% were black. In addition to inflammation, many patients had peripapillary atrophy (39%) or diskiform macular scars (32%). Of those with diskiform scars, 33% were black. Systemically, 32% of the patients were presumed to have sarcoidosis, 29%, tuberculosis; 11%, syphilis; and 28%, no etiology. In some cases, treatment of the underlying disease resulted in improvement of the ocular findings. Inflammatory pseudohistoplasmosis syndrome appears to be a nonspecific response to a number of uveitic syndromes, including sarcoidosis, tuberculosis and syphilis.

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