A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction
- 1 March 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 338 (6212) , 229-234
- https://doi.org/10.1038/338229a0
Abstract
A striking example of topographic specificity in synapse formation is the preferential reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor axons. This specificity is mediated by the basal lamina of the synaptic cleft. A glycoprotein, s-laminin, has now been iden-tified that is selectively associated with synaptic basal lamina and is recognized by motoneurons. Molecular cloning reveals that s-laminin is a novel homologue of laminin, a potent promoter of neurite outgrowth.Keywords
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