Membranous Nephropathy — Still a Treatment Dilemma

Publisher Website
Google Scholar
Abstract
Membranous nephropathy is found predominantly in middle-aged patients in association with proteinuria, which is often sufficient to induce a full nephrotic syndrome. It is characterized by immune aggregates on the outer, subepithelial aspect of the basement membrane of the glomerular capillaries and by an absence of cellular proliferation or infiltration of glomeruli by cells. Typically, it has an indolent course, evolving gradually toward renal failure in about one third to one half of patients and toward remission in the remainder.In rats, similar lesions can be induced by antibodies directed against antigens represented on the surface of glomerular epithelial cells . . .