Protein O- Mannosyltransferase Isoforms Regulate Biofilm Formation in Candida albicans
- 1 October 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (10) , 3488-3491
- https://doi.org/10.1128/aac.00606-06
Abstract
Five isoforms of protein mannosyltransferase (Pmt) O -mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.Keywords
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