Role of Calmodulin/Protein Kinase C in Interferon Production by Poly(rl) · Poly(rC) in Primed Human Cell Cultures
- 1 August 1990
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 10 (4) , 375-378
- https://doi.org/10.1089/jir.1990.10.375
Abstract
Human cells treated with trifluoperazine (TFP) or K252a prior to and/or during priming with human interferon-α (HuIFN-α) produce significantly more IFN on induction with poly(rI) · poly(rC) than primed cells in the absence of the drug. Results suggest that calmodulin/protein kinase activity may be involved in priming activity of HuIFN-α.This publication has 25 references indexed in Scilit:
- Effect of Calmodulin Antagonists on the Interferon System: Induction and Action of InterferonsJournal of Interferon Research, 1990
- Activators of Protein Kinase C Enhance Accumulation of Interferon-β mRNA in Murine Cell LinesJournal of Interferon Research, 1989
- The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon γ induction by poly I:poly CFEBS Letters, 1989
- Calcium and the Production of Interferon by Human Peripheral Blood Mononuclear CellsJournal of Interferon Research, 1988
- Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elementsCell, 1988
- Interferon Induction by Viruses. XVI. 2-Aminopurine Blocks Selectively and Reversibly an Early Stage in Interferon InductionJournal of General Virology, 1988
- Regulation of two interferon‐inducible human genes by interferon, poly(rI) · poly(rC) and virusesEuropean Journal of Biochemistry, 1988
- 2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene ExpressionScience, 1988
- Priming Increases the Amount of Interferon mRNA in Poly(rI).poly(rC)-treated L CellsJournal of General Virology, 1979
- The Effect of Priming with Interferon on Interferon Production by Two Lines of L CellsJournal of General Virology, 1972