Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer
Open Access
- 9 September 2003
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 89 (6) , 1031-1034
- https://doi.org/10.1038/sj.bjc.6601195
Abstract
Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2–3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.Keywords
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