Glucose Stimulation of the Antilipolytic Effect of Insulin in Humans
- 3 June 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4601) , 1057-1059
- https://doi.org/10.1126/science.6342138
Abstract
Dose-response studies of the inhibition of lipolysis by insulin in isolated human adipocytes were conducted with the use of a sensitive bioluminescent assay of glycerol release. The addition of glucose to the incubation medium was associated with an increase in insulin sensitivity and an increase in the maximum insulin effect. The results suggest that glucose plays an important role in regulating the antilipolytic action of insulin in humans.This publication has 19 references indexed in Scilit:
- Marked Increase in Insulin Sensitivity of Human Fat Cells 1 Hour after Glucose IngestionJournal of Clinical Investigation, 1983
- The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvationMetabolism, 1981
- Insulin action on adipocytes. Evidence that the anti-lipolytic and lipogenic effects of insulin are mediated by the same receptorBiochemical Journal, 1979
- Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinctionMetabolism, 1978
- The Action of Insulin and Glucose on Lipolysis in Isolated Human Fat CellsHormone and Metabolic Research, 1974
- Human Adipose Tissue Dynamics and RegulationPublished by Elsevier ,1971
- Factors affecting lipolysis rates in rat adipose tissueBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Factors Affecting the Inhibitory Action of Insulin on Lipolysis in a Glucose-Free MediumEndocrinology, 1967
- Antilipolytic Effect of Insulin in Isolated Fat Cells of the RatEndocrinology, 1966
- Studies on the Metabolism of Adipose Tissue. XII. The Effects of Insulin and Epinephrine on Free Fatty Acid and Glycerol Production in the Presence and Absence of Glucose*Biochemistry, 1963