Chemistry,13C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica
- 30 June 1983
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 48 (07) , 136-141
- https://doi.org/10.1055/s-2007-969908
Abstract
From the leaves of Colubrina asiatica BRONGEN (Rhamnaceae) two saponins have been isolated and structurally elucidated, mainly by 13C-NMR-spectroscopic methods, as jujubogenin-3-O-[2-O-acetyl-3-O-(3-O-β-D-xylopyranosyl-4-O-acetyl-β-D-glucopyranosyl)-α-L-arabinoside] (colubrinoside) and jujubogenin-3-O- [2-O-acetyl -3-O- (2-O- β -D- xylopyranosyl-β-D-glucopyranosyl)-α-L-arabinoside] (colubrin) respectively. Both saponins inhibit the spontaneous motility of mice, even at low doses (1 mg/ kg), they show an antagonistic effect on amphetamine and exert a synergistic activity on chlordiazepoxide.Keywords
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