Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface.

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Abstract
In EM studies of the endothelial vesicles in frog mesenteric capillaries an accidental observation was made concerning vesicular organization. When tannic acid was added to fixed tissue the mordant reached apparently free vesicles in the cytoplasm under conditions in which vesicular movement was excluded and in which the impermeability of the cell membranes was preserved. This indicates a spatial continuity between the vesicles and the cell exterior. Cytoplasmic vesicles in endothelial cells apparently are elements of branching, permanent or semipermanent invaginations of the plasmalemma.