MORE than three years ago one of us (A.A.) and associates1published a report of 100 patients with tuberculoma of the central nervous system who has been treated in the Instituto Central de Neurocirurgia and Neuropatologia, up to July 1945 and we stated at that time that "with the progress of the methods of diagnosis and of neurosurgery and with the benefit of the medical treatment of tuberculosis, we are able to look ahead with more encouragement; the outlook stimulates our perseverance and challenges us to attempt more daring surgery." Little time has passed since the introduction of streptomycin, paraaminosalicylic acid and the sulfonamide drugs has obliged us to change our clinical and therapeutic procedure in the attack on this problem. According to Davis2and Bailey,3tuberculomas constituted 50 per cent of the new growths of the central nervous system at the close of the last century.