EFFECTS OF SEMISTARVATION AND PARENTERAL NUTRITION ON GASTRIC-MUCOSA OF RATS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 79  (3) , 306-309
Abstract
The effects of semistarvation and parenteral nutrition on the gastric mucosa were studied in 24 Wistar rats (250-350 g). The animals were divided into 3 dietary regimens: group I.sbd.standard rat chow ad lib.; group II.sbd.50 cm3 per day of a hyperalimentation solution containing 30% glucose + 5% amino acids; and group III.sbd.50 cm3 per day of 5% glucose. The animals were fed for a period of 7 days. Gastric mucosal fluxes of Na+, Li+ and H+ then were measured after the gastric instillation of 2 gastric wash solutions, one primarily on HCl solution, the other a solution of HCl plus sodium taurocholate. Gross examination of the gastric mucosal surfaces were recorded. Compared to group I (oral diet), groups II and III demonstrated a decrease in volume of gastric secretion during the test period (P < 0.005) and an increase in net negative H+ flux (P < 0.005). Compared to group II (hyperalimented), group III (semistarved) demonstrated an increased net negative H+ flux (P < 0.01), but no difference in volume of secretion. Only group III demonstrated a difference in H+ flux after the addition of sodium taurocholate (P < 0.005). Gastric lesions were significantly increased in group III, as compared to groups I and II. Semistarvation renders the gastric mucosa of the rat more susceptible to injury. Adequate i.v. nutrition alone protected against these effects.