Substance P and peripheral inflammatory hyperalgesia

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Abstract
Aw to further challenges with small doses of SP, dopamine or prostacyclin. The sensitizing process also occurred after multiple injections of prostacyclin or prostaglandin E2. The sensitizing effect induced by SP, prostaglandin E2 or prostacyclin is inhibited by pre-treatment with the SP antagonist (d-Arg1, d-Pro2, d-Trp7,9, Leu11)-SP. We suggest that SP has an important role as a modulator in peripheral inflammatory pain by sensitizing nociceptors to its own action and to the action of different mediators. This sensitizing process could also be associated with chronic inflammatory pain. ∗Correspondence to: Meire Nakamura-Craig, Department of Pharmacology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. 1Present address: British Technology Group, London SE1 6BU U.K. Submitted September 27, 1988; revised December 19, 1988; accepted February 10, 1989. © Lippincott-Raven Publishers....