Immunological relationships between glycopeptides ofMicrosporum canis, Trichophyton rubrum, Trichophyton mentagrophytesand other fungi
- 1 January 1968
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 6 (2) , 119-126
- https://doi.org/10.1080/00362176885190221
Abstract
Allergenic glycopeptides have been extracted from cultures of Trichophyton mentagrophytes, T. rubrum, T. schoenleinii, Microsporum canis, Keratinomyces ajelloi and Epidermophyton floccosum. These have very similar chemical structures and all give rise to both immediate and delayed hypersensitivity reactions in sensitised guinea pigs. A range of polysaccharides from other sources was tested in guinea pigs sensitised to dermatophytes. None gave delayed reactions, but some with structural features in common with those isolated from dermatophytes gave immediate reactions. Allergenische Glycopeptide wurden aus Kulturen von Trichophyton mentagrophytes, T. rubrum, T. schoenleinii, Microsporum canis, Keratinomyces ajelloi und Epidermophyton floccosum extrahiert. Diese haben sehr ähnliche chemische Strukturen und bewirken alle bei sensibilisierten Meerschweinchen Ueberempfindlichkeitsreaktionen vom Sofort-und Spättyp. Eine Anzahl von Polysacchariden anderer Herkunft wurde an Meerschweinchen geprüft, die gegen Dermatophyten sensibilisiert waren. Keines führte zu Spätreaktionen, aber einige Proben mit gleichen Struktureigenschaften wie Material aus Dermatophyten bewirkten Sofortreaktionen.Keywords
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