Thymic Function after Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency

Open Access

4 May 2000

journal article
research article
Published by Massachusetts Medical Society in New England Journal of Medicine

Vol. 342 (18) , 1325-1332
https://doi.org/10.1056/nejm200005043421804

Abstract

Immune function can be restored in infants with severe combined immunodeficiency by transplantation of unfractionated bone marrow from HLA-identical donors or T-cell–depleted marrow stem cells from haploidentical donors, with whom there is a single haplotype mismatch, without the need for chemotherapy before transplantation or prophylaxis against graft-versus-host disease. The role of the thymus in this process is unknown.

Keywords

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