Synthesis and Studies of Alkynyl Pyrimidinones as Metaphase Inhibitors.

Publisher Website
Google Scholar
Abstract
Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mitosis in the metaphase of the cell-cycle. The in vivo screening was on Chang liver cells.

This publication has 0 references indexed in Scilit: