Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency
- 1 May 1972
- journal article
- Published by Wiley in Clinical Genetics
- Vol. 3 (3) , 188-200
- https://doi.org/10.1111/j.1399-0004.1972.tb01458.x
Abstract
Serum high density lipoproteins (HDL) from three patients with lecithin: cholesterol acyltransferase (LCAT) deficiency have been studied. HDL from the patients is composed of two components, one of high molecular weight (HM‐HDL) and one of relatively low molecular weight (LM‐HDL). The polypeptides of lipid‐free HDL (apoHDL) from normal subjects were indistinguishable from those of apoHM‐HDL from the patients as judged by treatment with 8 M urea and gel filtration on Sephadex G‐200, immunological experiments, disc electrophoresis, and amino acid analysis. ApoLM‐HDL contained mainly the apoA‐I polypeptide with small amounts of apoA‐II, whereas C‐polypeptides were lacking. The results indicate that the presence of apparently “abnormal” HDL particles in serum of the patients is secondary to the lack of LCAT activity.This publication has 34 references indexed in Scilit:
- Amino acid composition of serum high density lipoprotein in patients with familial lecithin:cholesterol acyltransferase deficiencyClinical Genetics, 2008
- Purification and substrate specificity of lecithin—cholesterol acyl transferase from human plasmaFEBS Letters, 1971
- Studies of the composition and structure of plasma lipoproteins. C‐ and N‐terminal amino acids of the two nonidentical polypeptides of human plasma apolipoprotein AFEBS Letters, 1971
- Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by electron microscopyJournal of Clinical Investigation, 1971
- Plasma lipoproteins in familial lecithin:cholesterol acyltransferase deficiency: lipid composition and reactivity in vitroJournal of Clinical Investigation, 1970
- FAMILIAL LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCYActa Medica Scandinavica, 1970
- Presence of α1-Lipoprotein in Patients with Familial Plasma Lecithin:Cholesterol Acyltransferase DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1969
- FAMILIAL SERUM CHOLESTEROL ESTER DEFICIENCYActa Medica Scandinavica, 1968
- Identifizierung eines Lipoproteins mit Antigenwirksamkeit im Lp-SystemHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1968
- Familial Plasma Lecithin: Cholesterol Acyltransferase Deficiency Biochemical Study of a New Inborn Error of MetabolismScandinavian Journal of Clinical and Laboratory Investigation, 1967