Cardiac myxomas: Immunohistochemical study of benign and malignant variants

1 November 1991

journal article
Published by Springer Nature in Virchows Archiv

Vol. 418 (6) , 485-491
https://doi.org/10.1007/bf01606497

Abstract

Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigens (neuron-specific enolase) in all tumour cells. Factor VIII was found in the endothelial cells of capillaries only. In the subendocardium of fetal heart tissue close to the foramen ovale myofibroblasts reacting with the panepithelial antibody lu-5 were detected. We conclude that CMs are neoplasms that may develop from embryonic cell remnants.

Keywords

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