ENHANCEMENT OF ADENYL-CYCLASE BY STEROID-THERAPY IN SHOCK

  • 1 January 1977
    • journal article
    • research article
    • Vol. 82  (4) , 483-488
Abstract
Hepatic and intestinal adenyl cyclase activity were measured after a single pulse injection of epinephrine or glucagon into normal dogs and into dogs subjected to hemorrhagic shock. Hemorrhagic shock apparently abolishes the increase in adenyl cyclase activity seen in normal animals following epinephrine and significantly reduces that induced by glucagon. These changes are reflected in glucose production from the liver induced by these hormones. Response of adenyl cyclase to in vitro addition of epinephrine or glucagon, as well as the nonspecific stimulator of adenyl cyclase, NaF, showed that it is the receptor site of the enzyme which is affected primarily by shock. Treatment of dogs with 30 mg/kg of methylprednisolone following reinfusion of shed blood significantly improved the response of adenyl cyclase to epinephrine in both liver and intestine, and this improvement was reflected in glucose production by the liver in response to the hormone.

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